Reactome | Arachidonate is epoxidated to 5,6-EET by CYP(4)

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Arachidonate is epoxidated to 5,6-EET by CYP(4) Show undefined attributes

catalystActivity	[CatalystActivity:10042715] monooxygenase activity of CYP(4) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10042717
displayName	Arachidonate is epoxidated to 5,6-EET by CYP(4)
eventOf	[Pathway:R-MMU-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-2161961] 5,6-EET is hydrolysed to 5,6-DHET by EPHX2 - Mus musculus
inferredFrom	[Reaction:R-HSA-2161890] Arachidonate is epoxidated to 5,6-EET by CYP(4) - Homo sapiens
input	[SimpleEntity:R-ALL-29768] AA [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Arachidonate is epoxidated to 5,6-EET by CYP(4) (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced (NADPH--hemoprotein reductase) => 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:R-ALL-2142739] 5,6-EET [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2161890
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
(precedingEvent)	[Reaction:R-MMU-2161961] 5,6-EET is hydrolysed to 5,6-DHET by EPHX2
(inferredTo)	[Reaction:R-HSA-2161890] Arachidonate is epoxidated to 5,6-EET by CYP(4)

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