Reactome | 5,6-EET is hydrolysed to 5,6-DHET by EPHX2

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5,6-EET is hydrolysed to 5,6-DHET by EPHX2 Show undefined attributes

catalystActivity	[CatalystActivity:10042768] epoxide hydrolase activity of EPHX2 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10042770
displayName	5,6-EET is hydrolysed to 5,6-DHET by EPHX2
eventOf	[Pathway:R-MMU-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2161961] 5,6-EET is hydrolysed to 5,6-DHET by EPHX2 - Homo sapiens
input	[SimpleEntity:R-ALL-2142739] 5,6-EET [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	5,6-EET is hydrolysed to 5,6-DHET by EPHX2
output	[SimpleEntity:R-ALL-2142682] 5,6-DHET [cytosol]
precedingEvent	[Reaction:R-MMU-2161890] Arachidonate is epoxidated to 5,6-EET by CYP(4) - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-2161961
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-2142670] Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)
(inferredTo)	[Reaction:R-HSA-2161961] 5,6-EET is hydrolysed to 5,6-DHET by EPHX2

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