Reactome | Endogenous sterols

Schema > Pathway > Entries

Endogenous sterols Show undefined attributes

compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol [Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10099625
displayName	Endogenous sterols
eventOf	[Pathway:R-MMU-211897] Cytochrome P450 - arranged by substrate type - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:13620] sterol metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-MMU-211951] CYP1B1 4-hydroxylates EST17b - Mus musculus [Reaction:R-MMU-192051] CYP7A1 7-hydroxylates CHOL - Mus musculus [Reaction:R-MMU-192065] CYP7B1 7-hydroxylates 25OH-CHOL - Mus musculus [Pathway:R-MMU-211994] Sterols are 12-hydroxylated by CYP8B1 - Mus musculus [Reaction:R-MMU-193101] CYP11A1 cleaves 20a,22b-DHCHOL - Mus musculus [Reaction:R-MMU-193997] CYP11B1 oxidises 11DCORT - Mus musculus [Reaction:R-MMU-194017] CYP11B2 oxidises 11DCORST to CORST - Mus musculus [Reaction:R-MMU-193995] CYP11B2 18-hydroxylates CORST to 18HCORST - Mus musculus [Reaction:R-MMU-193965] CYP11B2 oxidises 18HCORST to ALDO - Mus musculus [Reaction:R-MMU-193060] CYP19A1 hydroxylates ANDST to E1 - Mus musculus [Reaction:R-MMU-193964] CYP21A2 21-hydroxylates PROG - Mus musculus [Reaction:R-MMU-192123] CYP27A1 27-hydroxylates CHOL - Mus musculus [Reaction:R-MMU-192178] CYP39A1 7-hydroxylates 24OH-CHOL - Mus musculus [Reaction:R-MMU-192061] CYP46A1 24-hydroxylates CHOL - Mus musculus [Reaction:R-MMU-194678] CYP51A1 demethylates LAN - Mus musculus [Reaction:R-MMU-6786239] CYP4V2 omega-hydroxylates DHA to HDoHE - Mus musculus
inferredFrom	[Pathway:R-HSA-211976] Endogenous sterols - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Endogenous sterols
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48892] Mus musculus
stId	R-MMU-211976
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-211897] Cytochrome P450 - arranged by substrate type
(inferredTo)	[Pathway:R-HSA-211976] Endogenous sterols

Cite Us!