Reactome | CYP1B1 4-hydroxylates EST17b

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CYP1B1 4-hydroxylates EST17b Show undefined attributes

catalystActivity	[CatalystActivity:10006846] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen of CYP1B1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10006848
displayName	CYP1B1 4-hydroxylates EST17b
eventOf	[Pathway:R-MMU-211976] Endogenous sterols - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-211951] CYP1B1 4-hydroxylates EST17b - Homo sapiens
input	[SimpleEntity:R-ALL-193132] EST17b [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP1B1 4-hydroxylates EST17b 17beta-estradiol + O2 + reduced (NADPH--hemoprotein reductase) => 4-hydroxy-17beta-estradiol + H(+) + H2O + oxidized (NADPH--hemoprotein reductase)
output	[SimpleEntity:R-ALL-211973] 4OH-EST17b [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
regulatedBy	[PositiveRegulation:9990541] Positive regulation by 'AHR:TCDD:ARNT [nucleoplasm]' [NegativeRegulation:9990542] Negative regulation by 'AHRR:ARNT [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-211951
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-211976] Endogenous sterols
(inferredTo)	[Reaction:R-HSA-211951] CYP1B1 4-hydroxylates EST17b

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