Reactome | Activation of TAK1-TAB2 complex

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Activation of TAK1-TAB2 complex Show undefined attributes

catalystActivity	[CatalystActivity:10004556] protein serine/threonine kinase activity of TAB2/TAK1 complex [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10004558
displayName	Activation of TAK1-TAB2 complex
eventOf	[Pathway:R-MMU-202424] Downstream TCR signaling - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-202500] Activation of IKK complex - Mus musculus
inferredFrom	[Reaction:R-HSA-202510] Activation of TAK1-TAB2 complex - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-MMU-202504] TAB2/TAK1 complex [cytosol] [Complex:R-MMU-202456] Ub-TRAF6 trimer bound to CBM complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of TAK1-TAB2 complex
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-MMU-202507] TAK1/TAB2 complex bound to TRAF6/CBM complex [plasma membrane]
precedingEvent	[Reaction:R-MMU-202453] Auto-ubiquitination of TRAF6 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-202510
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-202424] Downstream TCR signaling
(precedingEvent)	[Reaction:R-MMU-202500] Activation of IKK complex
(inferredTo)	[Reaction:R-HSA-202510] Activation of TAK1-TAB2 complex

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