Reactome | 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one

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7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one Show undefined attributes

catalystActivity	[CatalystActivity:10001327] 3-beta-hydroxy-Delta5-steroid dehydrogenase (NAD+) activity of HSD3B7 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10001329
displayName	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
eventOf	[Pathway:R-MMU-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-192033] 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one - Mus musculus [Reaction:R-MMU-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE - Mus musculus
inferredFrom	[Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one - Homo sapiens
input	[SimpleEntity:R-ALL-192114] 7 alpha-hydroxycholesterol [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-29360] NAD+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one
output	[SimpleEntity:R-ALL-192136] 4CHOL7aOLONE [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-73473] NADH [cytosol]
precedingEvent	[Reaction:R-MMU-192051] CYP7A1 7-hydroxylates CHOL - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-192097
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-193368] Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
(precedingEvent)	[Reaction:R-MMU-192033] 4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one [Reaction:R-MMU-192157] CYP8B1 12-hydroxylates 4CHOL7aOLONE
(inferredTo)	[Reaction:R-HSA-192097] 7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one

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