Reactome | E-cadherin degradation by MMP9, KLK7

Schema > Reaction > Entries

E-cadherin degradation by MMP9, KLK7 Show undefined attributes

catalystActivity	[CatalystActivity:10049525] metalloendopeptidase activity of MMP9, KLK7 [extracellular region]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10049527
displayName	E-cadherin degradation by MMP9, KLK7
eventOf	[Pathway:R-MMU-1474228] Degradation of the extracellular matrix - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3827958] E-cadherin degradation by MMP9, KLK7 - Homo sapiens
input	[Complex:R-MMU-2534182] CDH1(155-882):Ca2+ dimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	E-cadherin degradation by MMP9, KLK7
output	[Complex:R-MMU-2534301] E-cadherin strand dimer fragment 155-700 [plasma membrane] [Complex:R-MMU-2534305] E-cadherin strand dimer fragment 701-882 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-3827958
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-1474228] Degradation of the extracellular matrix
(inferredTo)	[Reaction:R-HSA-3827958] E-cadherin degradation by MMP9, KLK7

Cite Us!