Reactome | SH2B3 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1562562] LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] - Homo sapiens [Complex:R-HSA-9706266] active FLT3:SH2B3 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1562640] LNK binds to p-KIT and inhibit downstream signaling - Homo sapiens [Reaction:R-HSA-9706315] Active FLT3 binds to SH2B3 - Homo sapiens
created	[InstanceEdit:997250] Jupe, S, 2010-11-08
dbId	997241
displayName	SH2B3 [cytosol]
endCoordinate	575
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-997241] Sh2b3 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-CFA-997241] SH2B3 [cytosol] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-997241] SH2B3 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-SSC-997241] SH2B3 [cytosol] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-997241] sh2b3 [cytosol] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-997241] SH2B3 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-997241] Lnk [cytosol] - Drosophila melanogaster
maxDepth	1
memberOf	[DefinedSet:R-HSA-997265] SH2B family [cytosol] - Homo sapiens
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	SH2B3 SH2B adapter protein 3 Lnk SH2B3_HUMAN Lymphocyte-specific adapter protein Lnk
referenceEntity	[ReferenceGeneProduct:uniprot:Q9UQQ2] UniProt:Q9UQQ2 SH2B3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-997241
startCoordinate	1

(input)	[Reaction:R-HSA-9706315] Active FLT3 binds to SH2B3 [Reaction:R-HSA-1562640] LNK binds to p-KIT and inhibit downstream signaling
(hasComponent)	[Complex:R-HSA-9706266] active FLT3:SH2B3 [plasma membrane] [Complex:R-HSA-1562562] LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-997265] SH2B family [cytosol]

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