Reactome | sh2b3 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-1562562] LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] - Xenopus tropicalis [Complex:R-XTR-9706266] active FLT3:SH2B3 [plasma membrane] - Xenopus tropicalis
consumedByEvent	[Reaction:R-XTR-1562640] LNK binds to p-KIT and inhibit downstream signaling - Xenopus tropicalis [Reaction:R-XTR-9706315] Active FLT3 binds to SH2B3 - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10680466
displayName	sh2b3 [cytosol]
endCoordinate	575
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-997241] SH2B3 [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-XTR-997265] SH2B family [cytosol] - Xenopus tropicalis
name	sh2b3 SH2B3 A4QN29
referenceEntity	[ReferenceGeneProduct:uniprot:A4QN29] UniProt:A4QN29
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-997241
startCoordinate	1

(input)	[Reaction:R-XTR-9706315] Active FLT3 binds to SH2B3 [Reaction:R-XTR-1562640] LNK binds to p-KIT and inhibit downstream signaling
(hasComponent)	[Complex:R-XTR-9706266] active FLT3:SH2B3 [plasma membrane] [Complex:R-XTR-1562562] LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane]
(hasMember)	[DefinedSet:R-XTR-997265] SH2B family [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-997241] SH2B3 [cytosol]

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