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SH2B3 [cytosol]
Stable Identifier
R-HSA-997241
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SH2B adapter protein 3, Lnk, SH2B3_HUMAN, Lymphocyte-specific adapter protein Lnk
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
SH2B proteins bind JAK2 (Homo sapiens)
SH2B family [cytosol] (Homo sapiens)
SH2B3 [cytosol] (Homo sapiens)
SH2B family:p-Y813-JAK2 [cytosol] (Homo sapiens)
SH2B family [cytosol] (Homo sapiens)
SH2B3 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Negative regulation of FLT3 (Homo sapiens)
Active FLT3 binds to CBL (Homo sapiens)
active FLT3:SH2B3 [plasma membrane] (Homo sapiens)
SH2B3 [cytosol] (Homo sapiens)
Active FLT3 binds to SH2B3 (Homo sapiens)
SH2B3 [cytosol] (Homo sapiens)
active FLT3:SH2B3 [plasma membrane] (Homo sapiens)
SH2B3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)
LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
SH2B3 [cytosol] (Homo sapiens)
SH2B3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UQQ2 SH2B3
Gene Names
SH2B3, LNK
Chain
chain:1-575
Reference Genes
BioGPS Gene:10019 SH2B3
COSMIC (genes):SH2B3 SH2B3
CTD Gene:10019 SH2B3
dbSNP Gene:10019 SH2B3
ENSEMBL:ENSG00000111252 SH2B3
HGNC:29605 SH2B3
KEGG:hsa:10019 SH2B3
Monarch:10019 SH2B3
NCBI Gene:10019 SH2B3
OMIM:605093 SH2B3
UCSC:Q9UQQ2 SH2B3
Reference Transcript
RefSeq:NM_001291424.1 SH2B3
RefSeq:NM_005475.2 SH2B3
Other Identifiers
10019
11717408_at
11717409_at
11749731_a_at
16757098
203320_PM_at
203320_at
3431893
3431894
3431904
3431905
3431906
3431907
3431908
3431909
3431910
3431919
3431920
3431922
3431923
3431925
3431927
3431928
3431931
3431932
3431935
3431936
3431937
3431938
3431939
3431940
3431941
3431942
3431944
39428_at
7958749
A_14_P104888
A_14_P128825
A_23_P13946
A_24_P201739
GE54525
GO:0001780
GO:0002376
GO:0005068
GO:0005173
GO:0005515
GO:0005829
GO:0005886
GO:0007165
GO:0007169
GO:0008285
GO:0030097
GO:0030154
GO:0030159
GO:0035162
GO:0035556
GO:0035591
GO:0035702
GO:0035855
GO:0036016
GO:0038163
GO:0043409
GO:0046426
GO:0048821
GO:0048856
GO:0051898
GO:0060090
GO:0060218
GO:0060761
GO:0070100
GO:0090331
GO:1900235
GO:1904893
GO:1990782
GO:1990869
HMNXSV003053902
PH_hs_0001260
TC12000868.hg
Participates
as a member of
SH2B family [cytosol] (Homo sapiens)
as an input of
Active FLT3 binds to SH2B3 (Homo sapiens)
LNK binds to p-KIT and inhibit downstream signaling (Homo sapiens)
as a component of
active FLT3:SH2B3 [plasma membrane] (Homo sapiens)
LNK:p-7Y-KIT:sSCF dimer:p-7Y-KIT [plasma membrane] (Homo sapiens)
Inferred To
SH2B3 [cytosol]
(Bos taurus)
SH2B3 [cytosol]
(Canis familiaris)
SH2B3 [cytosol]
(Gallus gallus)
SH2B3 [cytosol]
(Sus scrofa)
Sh2b3 [cytosol]
(Mus musculus)
sh2b3 [cytosol]
(Xenopus tropicalis)
Lnk [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001278353.1
,
NP_005466.1
ENSEMBL
ENSP00000345492
,
ENST00000341259
OpenTargets
ENSG00000111252
HPA
ENSG00000111252-SH2B3
PRO
Q9UQQ2
Pharos - Targets
Q9UQQ2
Orphanet
SH2B3
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