Exosomal secretion of DENV RNA and proteins

Stable Identifier
R-HSA-9947387
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Dengue virus type 2
Compartment
cytosol, extracellular exosome
ReviewStatus
5/5
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Exosomal secretion of DENV RNA and proteins
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DENV genomic RNA (from DENV-2 and DENV-3 strains) and subgenomic RNA can be transferred by extracellular vesicles (EVs) from cell to cell, including transfer from mosquito cells to human cells and from hamster kidney cells (BHK) to human cells (Vora et al., 2018; Ishikawa et al., 2024; reviewed in Athira et al., 2024). EVs from human Huh7 cells infected with DENV strains (such as DENV-2 PL046; all four DENV serotypes can produce relevant vesicles) also contain viral proteins E, NS1, prM/M, as well as host lipid droplets and Microtubule-associated protein 1 light chain 3 beta (MAP1LC3B, LC3-II), an autophagy marker (Wu et al., 2016).
Literature References
PubMed ID Title Journal Year
39225901 Dual Role of Extracellular Vesicles as Orchestrators of Emerging and Reemerging Virus Infections

Athira, AP, Sreekanth, S, Chandran, A, Lahon, A

Cell Biochem Biophys 2025
29946031 Arthropod EVs mediate dengue virus transmission through interaction with a tetraspanin domain containing glycoprotein Tsp29Fb

Vora, A, Zhou, W, Londono-Renteria, B, Woodson, M, Sherman, MB, Colpitts, TM, Neelakanta, G, Sultana, H

Proc Natl Acad Sci U S A 2018
27558165 Autophagy-associated dengue vesicles promote viral transmission avoiding antibody neutralization

Wu, YW, Mettling, C, Wu, SR, Yu, CY, Perng, GC, Lin, YS, Lin, YL

Sci Rep 2016
38675867 Dissemination of the Flavivirus Subgenomic Replicon Genome and Viral Proteins by Extracellular Vesicles

Ishikawa, T, Narita, K, Matsuyama, K, Masuda, M

Viruses 2024
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
exosomal secretion (1990182)
Disease
Name Identifier Synonyms
dengue disease DOID:12205 breakbone fever, Dengue Fever, classic dengue
Cross References
Mondo
Authored
Stephan, R  (2025-05-04)
Reviewed
Mansur, DS  (2025-09-18)
Roque Ascenção, F  (2025-10-29)
Roque Ascenção, F  (2026-03-03)
Created
Stephan, R  (2025-05-05)
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