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Alamandine is a decarboxylated form of the heptapeptide AGT(... Show undefined attributes

created	[InstanceEdit:9944543] May, Bruce, 2025-04-05
dbId	9944561
displayName	Alamandine is a decarboxylated form of the heptapeptide AGT(...
literatureReference	[LiteratureReference:9944533] Alamandine, a protective component of the renin-angiotensin system, reduces cellular proliferation and interleukin-6 secretion in human macrophages through MasR-MrgDR heteromerization [LiteratureReference:9944765] Structural insight into the activation mechanism of MrgD with heterotrimeric Gi-protein revealed by cryo-EM [LiteratureReference:9944761] High-affinity agonists reveal recognition motifs for the MRGPRD GPCR [LiteratureReference:9944487] Adipose tissue plasticity mediated by the counterregulatory axis of the renin-angiotensin system: Role of Mas and MrgD receptors [LiteratureReference:9944541] Alternative Renin-Angiotensin System
modified	[InstanceEdit:9945058] May, Bruce, 2025-04-09
schemaClass	Summation
text	Alamandine is a decarboxylated form of the heptapeptide AGT(25-31) (Angiotensin-(1-7), amino acid sequence Ala-Arg-Val-Tyr-Ile-His-Pro) that binds the G protein coupled receptor MRGPRD (MrgD) (Lautner et al.2013). The binding of Alamandine to MRGPRD causes cellular release of nitric oxide, a vasodilator (Lautner et al. 2013). Alamandine also interacts with a MAS1:MRGPRD heterodimer (Rukavina Mikusic et al. 2024). MRGPRD interacts with Galpha(i) (Suzuki et al. 2022) and Galpha(q) (Wang et al. 2024). Alamanidine and MRGPRD are components of the counter-regulatory system within the renin-angiotensin system (reviewed in Bader et al. 2024, Proen�a et al. 2024), however, their physiological roles are not well characterized.

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[Reaction:R-HSA-9944544] Alamandine binds MRGPRD (MrgD)

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