Reactome | ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)

Schema > Reaction > Entries

ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31) Show undefined attributes

authored	[InstanceEdit:9944526] May, Bruce, 2025-04-04
catalystActivity	[CatalystActivity:2022376] metallocarboxypeptidase activity of ACE2(18-805):Zn2+ dimer [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9944543] May, Bruce, 2025-04-05
dbId	9944488
displayName	ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)
edited	[InstanceEdit:9944526] May, Bruce, 2025-04-04
eventOf	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins - Homo sapiens
followingEvent	[Reaction:R-HSA-9944544] Alamandine binds MRGPRD (MrgD) - Homo sapiens
input	[GenomeEncodedEntity:R-HSA-9944499] 1-Ala-AGT(25-32) [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9944511] Discovery and characterization of alamandine: a novel component of the renin-angiotensin system
maxDepth	1
modified	[InstanceEdit:9976048] May, Bruce, 2025-12-06
name	ACE2:Zn2+ cleaves 1-Ala-AGT(25-32) to yield Alamandine (1-Ala-AGT(25-31)
output	[GenomeEncodedEntity:R-HSA-9944519] Alamandine [extracellular region] [SimpleEntity:R-ALL-351993] L-Phe [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-9944540] AGT(25-32) is decarboxylated to yield 1-Ala-AGT(25-32) (des(Asp1)-(Ala1)-Ang II, Angiotensin A) - Homo sapiens
releaseDate	2025-06-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9945952] Bader, Michael, 2025-04-20 [InstanceEdit:9945955] Santos, Robson Augusto Souza, 2025-04-20 [InstanceEdit:9945958] Touyz, Rhian M, 2025-04-20
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9944488
summation	[Summation:9944587] ACE2 cleaves the C-terminal phenylalanine residue from 1-Ala...

Referrals

(hasEvent)	[Pathway:R-HSA-2022377] Metabolism of Angiotensinogen to Angiotensins
(precedingEvent)	[Reaction:R-HSA-9944544] Alamandine binds MRGPRD (MrgD)

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