Reactome | FBXL21:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2

Schema > Reaction > Entries

authored	[InstanceEdit:9932581] May, Bruce, 2024-12-20
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9932863] May, Bruce, 2024-12-20
dbId	9932869
displayName	FBXL21:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2
edited	[InstanceEdit:9932581] May, Bruce, 2024-12-20
eventOf	[Pathway:R-HSA-9932298] Degradation of CRY and PER proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9932859] FBXL21:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9932860] Fbxl21:Cul1:Skp1:Rbx1 binds phosphorylated Cry1,2 - Mus musculus
input	[Complex:R-HSA-9932885] FBXL21:CUL1:SKP1:RBX1 [cytosol] [DefinedSet:R-HSA-400287] p-CRY1,p-CRY2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	FBXL21:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2
output	[Complex:R-HSA-9932864] FBXL21:CUL1:SKP1:RBX1:p-S-CRY1,2 [cytosol]
precedingEvent	[Reaction:R-HSA-9909369] CSNK1E,CSNK1D phosphorylate CRY and PER proteins - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9932869
summation	[Summation:9933325] FBXL21, the substrate recognition component of the FBXL21:CU...

(hasEvent)	[Pathway:R-HSA-9932298] Degradation of CRY and PER proteins
(precedingEvent)	[BlackBoxEvent:R-HSA-9932859] FBXL21:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2
(inferredTo)	[Reaction:R-MMU-9932860] Fbxl21:Cul1:Skp1:Rbx1 binds phosphorylated Cry1,2

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