Reactome | CSNK1E,CSNK1D phosphorylate CRY and PER proteins

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CSNK1E,CSNK1D phosphorylate CRY and PER proteins Show undefined attributes

authored	[InstanceEdit:9909367] May, Bruce, 2024-05-11
catalystActivity	[CatalystActivity:9933502] protein serine/threonine kinase activity of CRY1:CRY2:PER1:p-S396-PER2:PER3:CSNK1E,CSNK1D [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9909380] May, Bruce, 2024-05-13
dbId	9909369
deleted	[Deleted:9938768] Deletion of instance: 400382
displayName	CSNK1E,CSNK1D phosphorylate CRY and PER proteins
edited	[InstanceEdit:9909367] May, Bruce, 2024-05-11
eventOf	[Pathway:R-HSA-9931530] Phosphorylation and nuclear translocation of the CRY:PER:kinase complex - Homo sapiens
followingEvent	[Reaction:R-HSA-9932506] BTRC:CUL1:SKP1:RBX1 binds phosphorylated PER protein - Homo sapiens [Reaction:R-HSA-9932869] FBXL21:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2 - Homo sapiens [BlackBoxEvent:R-HSA-9909565] p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus - Homo sapiens
inferredFrom	[Reaction:R-MMU-9909394] Csnk1e,Csnk1d phosphorylate Cry and Per proteins - Mus musculus
input	10 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9909381] CRY1:CRY2:PER1:p-S396-PER2:PER3:CSNK1E,CSNK1D [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:400293] Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts [LiteratureReference:508355] CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock [LiteratureReference:508347] An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome [LiteratureReference:508333] Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2 [LiteratureReference:508733] Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome [LiteratureReference:508746] Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon [LiteratureReference:9920648] CK1?/? protein kinase primes the PER2 circadian phosphoswitch
maxDepth	1
modified	[InstanceEdit:9939392] May, Bruce, 2025-02-26
name	CSNK1E,CSNK1D phosphorylate CRY and PER proteins
output	10 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9909377] p-S-CRY1:p-S-CRY2:p-S-PER1:p-7S-PER2:p-S-PER3:CSNK1E,CSNK1D [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-9909392] Formation of CRY:PER:Kinase complex - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeRegulation:R-HSA-5656529] Negative regulation by 'PP1 catalytic subunit [cytosol]' [PositiveRegulation:9925658] Positive regulation by 'Casein kinase II [cytosol]'
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9909369
summation	[Summation:9930072] In the cytosol the kinases casein kinase I delta (CSNK1D) an...

Referrals

(replacementInstances)	[Deleted:9938768] Deletion of instance: 400382
(precedingEvent)	[Reaction:R-HSA-9932506] BTRC:CUL1:SKP1:RBX1 binds phosphorylated PER protein [Reaction:R-HSA-9932869] FBXL21:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2 [BlackBoxEvent:R-HSA-9909565] p-S-CRY:p-S-PER:CSNK1D,E complex translocates from the cytosol to the nucleus
(hasEvent)	[Pathway:R-HSA-9931530] Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
(inferredTo)	[Reaction:R-MMU-9909394] Csnk1e,Csnk1d phosphorylate Cry and Per proteins