Reactome | FBXL21:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2

Schema > BlackBoxEvent > Entries

FBXL21:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2 Show undefined attributes

authored	[InstanceEdit:9932581] May, Bruce, 2024-12-20
category	uncertain
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9932863] May, Bruce, 2024-12-20
dbId	9932859
deleted	[Deleted:9938736] Deletion of instance: 400282
displayName	FBXL21:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2
edited	[InstanceEdit:9932581] May, Bruce, 2024-12-20
eventOf	[Pathway:R-HSA-9932298] Degradation of CRY and PER proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9934887] Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9932872] Fbxl21:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2 - Mus musculus
input	[Complex:R-HSA-9932864] FBXL21:CUL1:SKP1:RBX1:p-S-CRY1,2 [cytosol] 3 × [Complex:R-HSA-8939319] Ub:UBE2D1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	FBXL21:CUL1:SKP1:RBX1 ubiquitinylates phosphorylated CRY1,2
output	[Complex:R-HSA-9932885] FBXL21:CUL1:SKP1:RBX1 [cytosol] [DefinedSet:R-HSA-9932868] K48polyUb-K107,p-S-CRY1;K48polyUb-K126,p-S-CRY2 [cytosol] 3 × [EntityWithAccessionedSequence:R-HSA-174236] UBE2D1 [cytosol]
precedingEvent	[Reaction:R-HSA-9932869] FBXL21:CUL1:SKP1:RBX1 binds phosphorylated CRY1,2 - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9932859
summation	[Summation:9933319] The SCF ubiquitin E3 ligase complex FBXL21:CUL1:SKP1:RBX1 po...

Referrals

(replacementInstances)	[Deleted:9938736] Deletion of instance: 400282
(hasEvent)	[Pathway:R-HSA-9932298] Degradation of CRY and PER proteins
(precedingEvent)	[BlackBoxEvent:R-HSA-9934887] Proteolysis of K48polyUb-K107,p-S-CRY1,K48polyUb-K126,p-S-CRY2
(inferredTo)	[BlackBoxEvent:R-MMU-9932872] Fbxl21:Cul1:Skp1:Rbx1 ubiquitinylates phosphorylated Cry1,2

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