Reactome | SPOP-mediated proteasomal degradation of PD-L1(CD274)

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SPOP-mediated proteasomal degradation of PD-L1(CD274) Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927346] Tiwari, Krishna, 2024-11-05
created	[InstanceEdit:9929494] Tiwari, Krishna, 2024-11-26
dbId	9929491
displayName	SPOP-mediated proteasomal degradation of PD-L1(CD274)
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9909615] Regulation of PD-L1(CD274) Post-translational modification - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9929482] CDK4:CCND1 phosphorylates SPOP - Homo sapiens [Reaction:R-HSA-9929487] p-S6-SPOP binds YWHAG - Homo sapiens [Reaction:R-HSA-9929484] SPOP:CUL3:RBX1 binds to CD274 - Homo sapiens [Reaction:R-HSA-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex - Homo sapiens [Reaction:R-HSA-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Homo sapiens [Reaction:R-HSA-9931418] CK2 phosphorylates CD274 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935361] Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance
maxDepth	2
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SPOP-mediated proteasomal degradation of PD-L1(CD274)
orthologousEvent	[Pathway:R-DDI-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Dictyostelium discoideum [Pathway:R-CEL-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Caenorhabditis elegans [Pathway:R-DME-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Drosophila melanogaster [Pathway:R-GGA-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Gallus gallus [Pathway:R-XTR-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Xenopus tropicalis [Pathway:R-DRE-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Danio rerio [Pathway:R-SSC-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Sus scrofa [Pathway:R-BTA-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Bos taurus [Pathway:R-CFA-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Canis familiaris [Pathway:R-RNO-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Rattus norvegicus [Pathway:R-MMU-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Mus musculus
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9929491
summation	[Summation:9937956] SPOP:CUL3:RBX1 E3 ubiquitin ligase complex regulates the ubi...

Referrals

(hasEvent)

[Pathway:R-HSA-9909615] Regulation of PD-L1(CD274) Post-translational modification