Reactome | SPOP-mediated proteasomal degradation of PD-L1(CD274)

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SPOP-mediated proteasomal degradation of PD-L1(CD274) Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10225501
displayName	SPOP-mediated proteasomal degradation of PD-L1(CD274)
eventOf	[Pathway:R-RNO-9909615] Regulation of PD-L1(CD274) Post-translational modification - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-9929482] CDK4:CCND1 phosphorylates SPOP - Rattus norvegicus [Reaction:R-RNO-9929487] p-S6-SPOP binds YWHAG - Rattus norvegicus [Reaction:R-RNO-9929484] SPOP:CUL3:RBX1 binds to CD274 - Rattus norvegicus [Reaction:R-RNO-9929490] CD274 ubiquitination by SPOP:CUL3:RBX1 complex - Rattus norvegicus [Reaction:R-RNO-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Rattus norvegicus [Reaction:R-RNO-9931418] CK2 phosphorylates CD274 - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SPOP-mediated proteasomal degradation of PD-L1(CD274)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9929491
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9909615] Regulation of PD-L1(CD274) Post-translational modification
(inferredTo)	[Pathway:R-HSA-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274)

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