Reactome | SPOP-mediated degradation of CD274 by 26S Proteosome

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SPOP-mediated degradation of CD274 by 26S Proteosome Show undefined attributes

authored	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26 [InstanceEdit:9927346] Tiwari, Krishna, 2024-11-05
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9929494] Tiwari, Krishna, 2024-11-26
dbId	9929486
displayName	SPOP-mediated degradation of CD274 by 26S Proteosome
edited	[InstanceEdit:9962761] Gillespie, Marc E, 2025-08-08
eventOf	[Pathway:R-HSA-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274) - Homo sapiens
input	[Complex:R-HSA-9929485] polyUb-PDL1:SPOP:CUL3:RBX1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9935361] Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance [LiteratureReference:9935375] CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	SPOP-mediated degradation of CD274 by 26S Proteosome
orthologousEvent	[Reaction:R-DDI-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Dictyostelium discoideum [Reaction:R-CEL-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Caenorhabditis elegans [Reaction:R-DME-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Drosophila melanogaster [Reaction:R-GGA-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Gallus gallus [Reaction:R-XTR-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Xenopus tropicalis [Reaction:R-DRE-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Danio rerio [Reaction:R-BTA-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Bos taurus [Reaction:R-RNO-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Rattus norvegicus [Reaction:R-MMU-9929486] SPOP-mediated degradation of CD274 by 26S Proteosome - Mus musculus
output	[Complex:R-HSA-9929377] SPOP:CUL3:RBX1 [cytosol] 3 × [DefinedSet:R-HSA-113595] Ub [cytosol]
releaseDate	2025-09-18
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9964122] Hung, Mien-Chie, Yamaguchi, Hirohito, 2025-08-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9929486
summation	[Summation:9937958] PD-L1 (CD274) polyubiquitinated by the SPOP:CUL3:RBX1 E3 ubi...

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(hasEvent)

[Pathway:R-HSA-9929491] SPOP-mediated proteasomal degradation of PD-L1(CD274)