SPOP:CUL3:RBX1 E3 ubiquitin ligase complex regulates the ubi...

created [InstanceEdit:9937955] Tiwari, Krishna, 2025-02-10
dbId 9937956
displayName SPOP:CUL3:RBX1 E3 ubiquitin ligase complex regulates the ubi...
literatureReference
modified [InstanceEdit:9938512] Tiwari, Krishna, 2025-02-17
schemaClass Summation
text SPOP:CUL3:RBX1 E3 ubiquitin ligase complex regulates the ubiquitination and degradation of PD-L1(CD274) protein. This is negatively regulated by Cyclin D:CDK4 complex which phosphorylates SPOP on Ser-6 (S6) and facilitates its sequestration by 14-3-3 protein gamma (Zhang et al., 2018), thus inhibiting SPOP-mediated recruitment in the E3 ubiquitin ligase complex.
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