Reactome | MITF-M-dependent BRCA1 gene expression

Schema > BlackBoxEvent > Entries

MITF-M-dependent BRCA1 gene expression Show undefined attributes

authored	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9926531] Rothfels, Karen, 2024-11-01
dbId	9926521
displayName	MITF-M-dependent BRCA1 gene expression
edited	[InstanceEdit:9927257] Rothfels, Karen, 2024-11-05
eventOf	[Pathway:R-HSA-9825895] Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6797612] BRCA1 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9926229] BRCA1 is a new MITF target gene [LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [LiteratureReference:9857252] Microphthalmia-associated transcription factor controls the DNA damage response and a lineage-specific senescence program in melanomas [LiteratureReference:9730403] MITF-the first 25 years
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent BRCA1 gene expression
output	[EntityWithAccessionedSequence:R-HSA-50949] BRCA1 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9926487] MITF-M binds the BRCA1 gene - Homo sapiens
regulatedBy	[PositiveGeneExpressionRegulation:9926449] Positive gene expression regulation by 'MITF-M dimer:BRCA1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9926463] Positive gene expression regulation by 'MITF-M dimer:BRCA1 gene [nucleoplasm]' Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9926521
summation	[Summation:9926308] BRCA1 expression is regulated by the binding of MITF-M dimer...

Referrals

(hasEvent)

[Pathway:R-HSA-9825895] Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence