Reactome | BRCA1 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

BRCA1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-912476] Synaptonemal Complex:BRCA1 [nucleoplasm] - Homo sapiens [Complex:R-HSA-912507] Meiotic single-stranded DNA complex [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-2997616] PIAS1,4 SUMOylates BRCA1 with SUMO2,3 - Homo sapiens [Reaction:R-HSA-2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 - Homo sapiens [Reaction:R-HSA-912467] BRCA1 is recruited to unsynapsed regions - Homo sapiens [Reaction:R-HSA-5659781] BRCA1 forms a heterodimer with BARD1 - Homo sapiens [FailedReaction:R-HSA-9699163] Defective BARD1 does not bind BRCA1 - Homo sapiens [BlackBoxEvent:R-HSA-912503] Formation of meiotic single-stranded DNA invasion complex - Homo sapiens
created	[InstanceEdit:75141] Matthews, L, 2003-08-11 05:43:00
dbId	50949
displayName	BRCA1 [nucleoplasm]
endCoordinate	1863
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-50949] Brca1 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-50949] Brca1 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-50949] BRCA1 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-50949] BRCA1 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-50949] BRCA1 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-XTR-50949] brca1 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-50949] BRCA1 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DDI-50949] BRCA1 [nucleoplasm] - Dictyostelium discoideum
maxDepth	1
memberOf	[CandidateSet:R-HSA-6797713] BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:3132750] Wu, G, 2013-02-13
name	BRCA1 Breast cancer type 1 susceptibility protein
negativelyRegulates	[NegativeRegulation:9817830] Negative regulation by 'BRCA1 [nucleoplasm]'
producedByEvent	[BlackBoxEvent:R-HSA-9926521] MITF-M-dependent BRCA1 gene expression - Homo sapiens [BlackBoxEvent:R-HSA-9007605] BRCA1 gene expression is inhibited by E2F6 - Homo sapiens [Reaction:R-HSA-9700998] BAP1 disrupts the BRCA1:BARD1 heterodimer - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P38398] UniProt:P38398 BRCA1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-50949
startCoordinate	1
updateTrackers	[UpdateTracker:9874775] Update Tracker - [EntityWithAccessionedSequence:50949] BRCA1 [nucleoplasm] - v44:[modifyEndCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9874775] Update Tracker - [EntityWithAccessionedSequence:50949] BRCA1 [nucleoplasm] - v44:[modifyEndCoordinate]
(input)	[Reaction:R-HSA-2997616] PIAS1,4 SUMOylates BRCA1 with SUMO2,3 [Reaction:R-HSA-2997709] PIAS1,4 SUMOylates BRCA1 with SUMO1 [FailedReaction:R-HSA-9699163] Defective BARD1 does not bind BRCA1 [BlackBoxEvent:R-HSA-912503] Formation of meiotic single-stranded DNA invasion complex [Reaction:R-HSA-912467] BRCA1 is recruited to unsynapsed regions [Reaction:R-HSA-5659781] BRCA1 forms a heterodimer with BARD1
(normalEntity)	[EntityFunctionalStatus:9663211] loss_of_function of BRCA1 mutants (BARD1 binding) [nucleoplasm]
(output)	[BlackBoxEvent:R-HSA-9926521] MITF-M-dependent BRCA1 gene expression [BlackBoxEvent:R-HSA-9007605] BRCA1 gene expression is inhibited by E2F6 [Reaction:R-HSA-9700998] BAP1 disrupts the BRCA1:BARD1 heterodimer
(regulator)	[NegativeRegulation:9817830] Negative regulation by 'BRCA1 [nucleoplasm]'
(hasComponent)	[Complex:R-HSA-912507] Meiotic single-stranded DNA complex [nucleoplasm] [Complex:R-HSA-912476] Synaptonemal Complex:BRCA1 [nucleoplasm] [Complex:R-HSA-5659802] BRCA1:BARD1 [nucleoplasm]
(hasMember)	[CandidateSet:R-HSA-6797713] BRCA1, ATR, FANCD2, FANCI, ATM, MDC1, CHEK1, RAD51D [nucleoplasm]
(activeUnit)	[CatalystActivity:9701027] ubiquitin-protein transferase activity of BRCA1:BARD1 [nucleoplasm]

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