BRCA1 expression is regulated by the binding of MITF-M dimer...

created [InstanceEdit:9926318] Rothfels, Karen, 2024-11-01
dbId 9926308
displayName BRCA1 expression is regulated by the binding of MITF-M dimer...
schemaClass Summation
text BRCA1 expression is regulated by the binding of MITF-M dimer to an E-box in intron 1, and silencing of MITF with siRNA abrogates expression of BRCA1 in human 501 Mel cells. (Strub et al, 2011; Beuret et al, 2011). BRCA1 expression may contribute to MITF-dependent suppression of DNA damage (Giuliano et al, 2010; reviewed in Goding and Arnheiter, 2019).
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