Dengue virus capsid protein (C) localizes to the nucleus in ...

created [InstanceEdit:9920209] Stephan, Ralf, 2024-08-29
dbId 9920206
displayName Dengue virus capsid protein (C) localizes to the nucleus in ...
modified [InstanceEdit:9966309] Stephan, Ralf, 2025-09-16
schemaClass Summation
text Dengue virus capsid protein (C) localizes to the nucleus in infected BHK-21 cells (Gabriel et al., 2020). While C is represented as a dimer in this reaction, its oligomerization state during transport is unknown. In the nucleus it interacts with host proteins like DAXX (Netsawang et al., 2010). The nucleolar localization of C occurs with all four serotypes of DENV (Tiwary & Cecilia, 2017, shown in BHK-21 cells). Importin-7 (IPO-7) has been shown to be required for this process in Huh7 cells (Itoh et al., 2024). While it is known that KPNB1 binds IPO-7 (Jäkel et al., 1999) the composition of the specific transport complex is unclear.

Metformin is a hypoglycemic drug approved for the treatment of type 2 diabetes and obesity. It inhibits nuclear import of Dengue C protein in vitro. The study involved DENV-2 and DENV-4 strains in human Huh-7 and monkey Vero cells. A mechanism related to changes in nuclear membrane/NPCs affecting passive transport was proposed (Puello-Nakayama et al., 2025).
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