Reactome | Formation of the dystrophin-glycoprotein complex (DGC)

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Formation of the dystrophin-glycoprotein complex (DGC) Show undefined attributes

authored	[InstanceEdit:9926574] Bhat, Hina F, 2024-11-01
created	[InstanceEdit:9913350] Rothfels, Karen, 2024-06-13
dbId	9913351
displayName	Formation of the dystrophin-glycoprotein complex (DGC)
doi	10.3180/R-HSA-9913351.1
edited	[InstanceEdit:9914712] Rothfels, Karen, 2024-06-26
eventOf	[Pathway:R-HSA-3000171] Non-integrin membrane-ECM interactions - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9913329] Autoproteolysis of DAG1 to alpha and beta chains - Homo sapiens [BlackBoxEvent:R-HSA-9913337] DAG1(30-653) and DAG1(654-895) translocate to the Golgi - Homo sapiens [Reaction:R-HSA-9913334] SGCB binds SGCD - Homo sapiens [Reaction:R-HSA-9913330] SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD - Homo sapiens [BlackBoxEvent:R-HSA-9913338] Sarcoglycan complex (SGC) translocates to the Golgi membrane - Homo sapiens [Reaction:R-HSA-9913332] DAG1(30-653), DAG1(654-895) and SSPN bind SGC - Homo sapiens [BlackBoxEvent:R-HSA-9913336] SGC:DAG1:SSPN complex translocates to plasma membrane - Homo sapiens [Reaction:R-HSA-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Homo sapiens [Reaction:R-HSA-9913333] DGC complex binds laminins - Homo sapiens [Reaction:R-HSA-9913335] DGC:laminin complex binds F-actin - Homo sapiens [Reaction:R-HSA-9914537] DGC complex binds AGRN and HSPG2 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9912926] ABC of multifaceted dystrophin glycoprotein complex (DGC) [LiteratureReference:9913318] The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction [LiteratureReference:9913307] The dystrophin-glycoprotein complex in brain development and disease [LiteratureReference:9913311] The molecular cross talk of the dystrophin-glycoprotein complex [LiteratureReference:2328093] Muscular dystrophies and the dystrophin-glycoprotein complex [LiteratureReference:2328126] Molecular basis of muscular dystrophies [LiteratureReference:9926571] The dystrophin-glycoprotein complex in the prevention of muscle damage
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Formation of the dystrophin-glycoprotein complex (DGC)
orthologousEvent	[Pathway:R-CEL-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Caenorhabditis elegans [Pathway:R-DME-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Drosophila melanogaster [Pathway:R-GGA-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Gallus gallus [Pathway:R-XTR-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Xenopus tropicalis [Pathway:R-DRE-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Danio rerio [Pathway:R-SSC-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Sus scrofa [Pathway:R-BTA-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Bos taurus [Pathway:R-CFA-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Canis familiaris [Pathway:R-RNO-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Rattus norvegicus [Pathway:R-MMU-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Mus musculus
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927641] Bhat, Hina F, 2024-11-08
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9913351
summation	[Summation:9913321] The dystrophin-glycoprotein complex (DGC, also known as DAPC...

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[Pathway:R-HSA-3000171] Non-integrin membrane-ECM interactions

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