Reactome | Formation of the dystrophin-glycoprotein complex (DGC)

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Formation of the dystrophin-glycoprotein complex (DGC) Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10996131
displayName	Formation of the dystrophin-glycoprotein complex (DGC)
eventOf	[Pathway:R-CEL-3000171] Non-integrin membrane-ECM interactions - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CEL-9913329] Autoproteolysis of DAG1 to alpha and beta chains - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9913337] DAG1(30-653) and DAG1(654-895) translocate to the Golgi - Caenorhabditis elegans [Reaction:R-CEL-9913334] SGCB binds SGCD - Caenorhabditis elegans [Reaction:R-CEL-9913330] SGCG,SGCZ and SGCA, SGCE bind SGCB:SGCD - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9913338] Sarcoglycan complex (SGC) translocates to the Golgi membrane - Caenorhabditis elegans [BlackBoxEvent:R-CEL-9913336] SGC:DAG1:SSPN complex translocates to plasma membrane - Caenorhabditis elegans [Reaction:R-CEL-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Caenorhabditis elegans [Reaction:R-CEL-9914537] DGC complex binds AGRN and HSPG2 - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Formation of the dystrophin-glycoprotein complex (DGC)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9913351
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-3000171] Non-integrin membrane-ECM interactions
(inferredTo)	[Pathway:R-HSA-9913351] Formation of the dystrophin-glycoprotein complex (DGC)

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