Reactome | Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC

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Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC Show undefined attributes

authored	[InstanceEdit:9926574] Bhat, Hina F, 2024-11-01
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9913331] Rothfels, Karen, 2024-06-13
dbId	9913339
displayName	Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC
edited	[InstanceEdit:9914712] Rothfels, Karen, 2024-06-26
eventOf	[Pathway:R-HSA-9913351] Formation of the dystrophin-glycoprotein complex (DGC) - Homo sapiens
followingEvent	[Reaction:R-HSA-9913333] DGC complex binds laminins - Homo sapiens
input	[CandidateSet:R-HSA-9913280] DMD, UTRN, (DRP2) [cytosol] [Complex:R-HSA-9630735] DTN:SNT complex [plasma membrane] [Complex:R-HSA-9913286] SGC:DAG1:SSPN complex [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9912923] A 71-kilodalton protein is a major product of the Duchenne muscular dystrophy gene in brain and other nonmuscle tissues [LiteratureReference:9926572] WW and EF hand domains of dystrophin-family proteins mediate dystroglycan binding [LiteratureReference:9912926] ABC of multifaceted dystrophin glycoprotein complex (DGC) [LiteratureReference:9913045] Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan [LiteratureReference:9912965] Identification and characterization of the dystrophin anchoring site on beta-dystroglycan [LiteratureReference:9913052] The interaction of dystrophin with beta-dystroglycan is regulated by tyrosine phosphorylation [LiteratureReference:9913051] Syntrophin binds to an alternatively spliced exon of dystrophin [LiteratureReference:9913071] The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives [LiteratureReference:9913747] Dystrobrevin and dystrophin: an interaction through coiled-coil motifs [LiteratureReference:9913749] Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane [LiteratureReference:9913743] Molecular organization at the glycoprotein-complex-binding site of dystrophin. Three dystrophin-associated proteins bind directly to the carboxy-terminal portion of dystrophin [LiteratureReference:2426614] Dystroglycan is a binding protein of laminin and merosin in peripheral nerve [LiteratureReference:9619577] Characterization of dystroglycan-laminin interaction in peripheral nerve [LiteratureReference:2396228] Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane [LiteratureReference:9619308] Specific disruption of a schwann cell dystrophin-related protein complex in a demyelinating neuropathy [LiteratureReference:9912946] Different dystrophin-like complexes are expressed in neurons and glia [LiteratureReference:9912951] Differential association of syntrophin pairs with the dystrophin complex [LiteratureReference:9913087] Biochemical evidence for association of dystrobrevin with the sarcoglycan-sarcospan complex as a basis for understanding sarcoglycanopathy [LiteratureReference:9912997] Interactions between dystrophin glycoprotein complex proteins [LiteratureReference:9912934] Assembly of multiple dystrobrevin-containing complexes in the kidney [LiteratureReference:9912938] Association of the Mr 58,000 postsynaptic protein of electric tissue with Torpedo dystrophin and the Mr 87,000 postsynaptic protein [LiteratureReference:9912994] Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins [LiteratureReference:9912986] Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions [LiteratureReference:9912980] In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4 [LiteratureReference:9913024] Nitric oxide in skeletal muscle
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC
orthologousEvent	[Reaction:R-MMU-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Mus musculus [Reaction:R-RNO-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Rattus norvegicus [Reaction:R-CFA-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Canis familiaris [Reaction:R-BTA-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Bos taurus [Reaction:R-SSC-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Sus scrofa [Reaction:R-XTR-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Xenopus tropicalis [Reaction:R-GGA-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Gallus gallus [Reaction:R-CEL-9913339] Recruitment of dystrophin, dystrobrevin and syntrophin proteins to the DGC - Caenorhabditis elegans
output	[Complex:R-HSA-9630743] DGC [plasma membrane]
precedingEvent	[BlackBoxEvent:R-HSA-9913336] SGC:DAG1:SSPN complex translocates to plasma membrane - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9927641] Bhat, Hina F, 2024-11-08
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9913339
summation	[Summation:9913215] Once at the plasma membrane, the core cytosolic components o...

Referrals

(precedingEvent)	[Reaction:R-HSA-9913333] DGC complex binds laminins
(hasEvent)	[Pathway:R-HSA-9913351] Formation of the dystrophin-glycoprotein complex (DGC)

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