Reactome | BTRC:CUL1:SKP1:RBX1 binds phosphorylated PER protein

Schema > Reaction > Entries

BTRC:CUL1:SKP1:RBX1 binds phosphorylated PER protein Show undefined attributes

authored	[InstanceEdit:9932311] May, Bruce, 2024-12-19
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9932525] May, Bruce, 2024-12-20
dbId	9932506
deleted	[Deleted:9938742] Deletion of instance: 400219
displayName	BTRC:CUL1:SKP1:RBX1 binds phosphorylated PER protein
edited	[InstanceEdit:9932311] May, Bruce, 2024-12-19
eventOf	[Pathway:R-HSA-9932298] Degradation of CRY and PER proteins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9932510] BTRC:CUL1:SKP1:RBX1 (SCF-beta-TrCP1) ubiquitinylates phosphorylated PER1,2,3 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9932534] Btrc:Cul1:Skp1:Rbx1 binds phosphorylated Per1,2,3 - Mus musculus
input	[Complex:R-HSA-9935060] BTRC,FBWX11:CUL1:RBX1:SKP1 [cytosol] [CandidateSet:R-HSA-9932493] p-S-PER1,2,3 [cytosol]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:400234] SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein
maxDepth	1
modified	[InstanceEdit:9938697] May, Bruce, 2025-02-18
name	BTRC:CUL1:SKP1:RBX1 binds phosphorylated PER protein
output	[Complex:R-HSA-9932521] BTRC,FBXW11:CUL1:RBX1:SKP1:p-S-PER1,2,3 [cytosol]
precedingEvent	[Reaction:R-HSA-9909369] CSNK1E,CSNK1D phosphorylate CRY and PER proteins - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2025-03-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9938389] Sancar, Aziz, 2025-02-14 [InstanceEdit:9938694] Albrecht, Urs, 2025-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9932506
summation	[Summation:9933174] Either the F-box homology protein BTRC (beta-TrCP) or FBXW11...

Referrals

(replacementInstances)	[Deleted:9938742] Deletion of instance: 400219
(hasEvent)	[Pathway:R-HSA-9932298] Degradation of CRY and PER proteins
(precedingEvent)	[BlackBoxEvent:R-HSA-9932510] BTRC:CUL1:SKP1:RBX1 (SCF-beta-TrCP1) ubiquitinylates phosphorylated PER1,2,3
(inferredTo)	[Reaction:R-MMU-9932534] Btrc:Cul1:Skp1:Rbx1 binds phosphorylated Per1,2,3

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