Recruitment of ITCH and K48 ubiquitination of MAVS

Stable Identifier
R-HSA-990526
Type
Reaction
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis C Virus, Measles virus
Compartment
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On viral infection PCB2 binds MAVS/IPS-1 and recruits the HECT domain-containing E3 ligase AIP4/ITCHY. AIP4 catalyses K48-polyubiquitination and degradation of MAVS. PCBP2 overexpression enhanced the interaction between MAVS and AIP4 and led to more degradation of MAVS. MAVS/IPS-1 regulation is very important in preventing excessive harmful immune responses.

Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

Sun, W, Jiang, Z, You, F, Liang, S, Sun, H, Zhai, Z, Zhou, X

Nat Immunol 2009
Participants
Participates
Catalyst Activity

ubiquitin protein ligase activity of ITCH [cytosol]

Orthologous Events
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