Reactome | Recruitment of ITCH and K48 ubiquitination of MAVS

Recruitment of ITCH and K48 ubiquitination of MAVS

Stable Identifier

R-HSA-990526

Type

Reaction

Species

Homo sapiens

Related Species

Influenza A virus, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

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Recruitment of ITCH and K48 ubiquitination of MAVS

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On viral infection PCB2 binds MAVS/IPS-1 and recruits the HECT domain-containing E3 ligase AIP4/ITCHY. AIP4 catalyses K48-polyubiquitination and degradation of MAVS. PCBP2 overexpression enhanced the interaction between MAVS and AIP4 and led to more degradation of MAVS. MAVS/IPS-1 regulation is very important in preventing excessive harmful immune responses.

Literature References

PubMed ID	Title	Journal	Year
19881509	PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 Sun, W, Jiang, Z, You, F, Liang, S, Sun, H, Zhai, Z, Zhou, X	Nat Immunol	2009