Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1

Stable Identifier
R-HSA-990526
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Rotavirus, Influenza A virus, Hepatitis C Virus, Measles virus
Compartment
cytosol, mitochondrial outer membrane
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Recruitment of AIP4 and K48 ubiquitination of MAVS/IPS-1
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On viral infection PCB2 binds MAVS/IPS-1 and recruits the HECT domain-containing E3 ligase AIP4/ITCHY. AIP4 catalyses K48-polyubiquitination and degradation of MAVS. PCBP2 overexpression enhanced the interaction between MAVS and AIP4 and led to more degradation of MAVS. MAVS/IPS-1 regulation is very important in preventing excessive harmful immune responses.

Literature References
PubMed ID Title Journal Year
19881509 PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4

You, F, Sun, H, Zhou, X, Sun, W, Liang, S, Zhai, Z, Jiang, Z

Nat Immunol 2009
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of ITCH [cytosol]
Physical Entity
ITCH [cytosol]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
ITCH homolog downregulates MDA5/IPS1 signaling (Gallus gallus)
Authored
Garapati, P V  (2010-08-02)
Reviewed
Kawai, T  (2010-10-30)
Akira, S  (2010-10-30)
Created
Garapati, P V  (2010-11-03)