Reactome | Recruitment of ITCH and K48 ubiquitination of MAVS

Recruitment of ITCH and K48 ubiquitination of MAVS

Stable Identifier

R-HSA-990526

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Influenza A virus, Human respiratory syncytial virus A, Rotavirus, Hepatitis C Virus, Measles virus

Compartment

cytosol, mitochondrial outer membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Recruitment of ITCH and K48 ubiquitination of MAVS

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

On viral infection PCB2 binds MAVS (IPS-1) and recruits the HECT domain-containing E3 ligase ITCH (AIP4). ITCH catalyses K48-polyubiquitination and degradation of MAVS. PCBP2 overexpression enhanced the interaction between MAVS and ITCH (AIP4) and led to more degradation of MAVS. MAVS (IPS-1) regulation is very important in preventing excessive harmful immune responses.

Literature References

PubMed ID	Title	Journal	Year
19881509	PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4 You, F, Sun, H, Zhou, X, Sun, W, Liang, S, Zhai, Z, Jiang, Z	Nat Immunol	2009