Reactome | Lipo-K105-DBT [mitochondrial matrix]

Schema > EntityWithAccessionedSequence > Entries

Lipo-K105-DBT [mitochondrial matrix] Show undefined attributes

compartment	[Compartment:5460] mitochondrial matrix
componentOf	[Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens [Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV - Homo sapiens [FailedReaction:R-HSA-9865121] BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA - Homo sapiens
dbId	70017
deleted	[Deleted:508270] Deletion of instances: 70056, 70048, 70038, 70035, 70018
displayName	Lipo-K105-DBT [mitochondrial matrix]
endCoordinate	482
hasModifiedResidue	[ModifiedResidue:508256] N6-lipoyl-L-lysine at 105
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-70017] Lipo-K105-DBT [mitochondrial matrix] - Mus musculus [EntityWithAccessionedSequence:R-RNO-70017] Dbt [mitochondrial matrix] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-70017] DBT [mitochondrial matrix] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-70017] Lipo-K105-DBT [mitochondrial matrix] - Bos taurus [EntityWithAccessionedSequence:R-SSC-70017] DBT [mitochondrial matrix] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-70017] dbt [mitochondrial matrix] - Danio rerio [EntityWithAccessionedSequence:R-XTR-70017] dbt [mitochondrial matrix] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-70017] DBT [mitochondrial matrix] - Gallus gallus [EntityWithAccessionedSequence:R-DME-70017] Dbct [mitochondrial matrix] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-70017] Lipo-K105-DBT [mitochondrial matrix] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-70017] bkdC [mitochondrial matrix] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-PFA-70017] Lipo-K105-DBT [mitochondrial matrix] - Plasmodium falciparum
literatureReference	[LiteratureReference:508263] Differential processing of human and rat E1 alpha precursors of the branched-chain alpha-keto acid dehydrogenase complex caused by an N-terminal proline in the rat sequence [LiteratureReference:508260] Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex
maxDepth	1
memberOf	[DefinedSet:R-HSA-6792580] Lipoylated DBT/DLST [mitochondrial matrix] - Homo sapiens
modified	[InstanceEdit:9858750] Stephan, Ralf, 2024-01-14
name	Lipo-K105-DBT dihydrolipoamide branched chain transacylase E2 DBT
producedByEvent	[Reaction:R-HSA-9859172] DLD dimer dehydrogenates dihydrolipoyl - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P11182] UniProt:P11182 DBT
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-70017
startCoordinate	62
updateTrackers	[UpdateTracker:9882196] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v45:[addName] [UpdateTracker:9868795] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v32:[addHasModifiedResidue, addLiteratureReference, modifyEndCoordinate, modifyName, modifyStartCoordinate] [UpdateTracker:9892988] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v54:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9882196] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v45:[addName] [UpdateTracker:9868795] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v32:[addHasModifiedResidue, addLiteratureReference, modifyEndCoordinate, modifyName, modifyStartCoordinate] [UpdateTracker:9892988] Update Tracker - [EntityWithAccessionedSequence:70017] Lipo-K105-DBT [mitochondrial matrix] - v54:[modifyName]
(replacementInstances)	[Deleted:508270] Deletion of instances: 70056, 70048, 70038, 70035, 70018
(hasComponent)	[Complex:R-HSA-9907590] DLD mutant-BCKDH [mitochondrial matrix] [Complex:R-HSA-5693120] p-BCKDH [mitochondrial matrix] [Complex:R-HSA-70019] BCKDH [mitochondrial matrix]
(input)	[FailedReaction:R-HSA-9865121] BCKDHA or BCKDHB loss-of-function mutants don't synthesize BCAA-CoA [Reaction:R-HSA-9859148] BCKDHA:BCKDHB tetramer decarboxylates KIC, KMVA, KIV
(hasMember)	[DefinedSet:R-HSA-6792580] Lipoylated DBT/DLST [mitochondrial matrix]
(output)	[Reaction:R-HSA-9859172] DLD dimer dehydrogenates dihydrolipoyl
(activeUnit)	[CatalystActivity:9859164] acyltransferase activity, transferring groups other than amino-acyl groups of BCKDH [mitochondrial matrix]

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