MITF-M-dependent RAB27A expression

Stable Identifier
R-HSA-9856460
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, melanosome membrane
ReviewStatus
5/5
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MITF-M-dependent RAB27A expression
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RAB27A is a small GTPase with roles in melanosome localization. In its active, GTP-bound form it interacts with MYO5A and MLPH (also known as melanophilin) and the tripartite complex directs melanosomes to the ends of dendrites by virtue of the MYO5A:actin interaction. Cell peripheral localization facilitates the transfer of melanosomes out of the melanocytes into adjacent keratinocytes (Chiaverini et al, 2008; Alves et al, 2017; Bahadoran et al, 2001; Fukuda et al, 2002; Nagashima et al, 2002; Kuroda and Fukuda, 2004; reviewed in Seabra and Coudrier, 2004; Hume and Seabra, 2011).
RAB27A and MYO5A are both direct targets of MITF-M as assessed by ChIP, EMSA and reporter gene assay (Chiaverini et al, 2008; Strub et al, 2011; Alves et al, 2017; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
11266474 Rab27a: A key to melanosome transport in human melanocytes

Casaroli-Marano, R, Bille, K, Ballotti, R, Mantoux, F, Bahadoran, P, Ortonne, JP, Buscà, R, Aberdam, E, Yalman, N, de Saint-Basile, G

J Cell Biol 2001
12062444 Melanophilin directly links Rab27a and myosin Va through its distinct coiled-coil regions

Igarashi, M, Yi, Z, Takeuchi, T, Nagashima, K, Torii, S, Izumi, T, Okamoto, K

FEBS Lett 2002
21936787 Melanosomes on the move: a model to understand organelle dynamics

Seabra, MC, Hume, AN

Biochem Soc Trans 2011
11856727 Slac2-a/melanophilin, the missing link between Rab27 and myosin Va: implications of a tripartite protein complex for melanosome transport

Fukuda, M, Kuroda, TS, Mikoshiba, K

J Biol Chem 2002
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Ye, T, Cormont, M, Keime, C, Kobi, D, Davidson, I, Le Gras, S, Giuliano, S, Bonet, C, Bertolotto, C, Ballotti, R, Strub, T

Oncogene 2011
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Bertolotto, C, Cheli, Y, Ohanna, M, Ballotti, R

Pigment Cell Melanoma Res 2010
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
27939378 MYO5A Gene Is a Target of MITF in Melanocytes

Alves, CP, Yokoyama, S, Sousa, JF, Goedert, L, Fisher, DE, Pontes, CLS, Espreafico, EM

J Invest Dermatol 2017
15117313 Rab GTPases and myosin motors in organelle motility

Seabra, MC, Coudrier, E

Traffic 2004
15543135 Rab27A-binding protein Slp2-a is required for peripheral melanosome distribution and elongated cell shape in melanocytes

Fukuda, M, Kuroda, TS

Nat Cell Biol 2004
18281284 Microphthalmia-associated transcription factor regulates RAB27A gene expression and controls melanosome transport

Bertolotto, C, Bille, K, Abbe, P, Beuret, L, Busca, R, Flori, E, Chiaverini, C, Ballotti, R, Bahadoran, P, Ortonne, JP

J Biol Chem 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MITF-M dimer:RAB27A gene [nucleoplasm] (Homo sapiens)
Active Unit
MITF-M dimer [nucleoplasm]
Authored
Rothfels, K  (2023-12-21)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Steingrímsson, E  (2024-11-05)
Vu, HN  (2024-11-05)
Created
Rothfels, K  (2023-12-18)
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