RAB27A is a small GTPase with roles in melanosome localizati...

created [InstanceEdit:9856454] Rothfels, Karen, 2023-12-18
dbId 9856450
displayName RAB27A is a small GTPase with roles in melanosome localizati...
modified [InstanceEdit:9859417] Rothfels, Karen, 2024-01-19
schemaClass Summation
text RAB27A is a small GTPase with roles in melanosome localization. In its active, GTP-bound form it interacts with MYO5A and MLPH (also known as melanophilin) and the tripartite complex directs melanosomes to the ends of dendrites by virtue of the MYO5A:actin interaction. Cell peripheral localization facilitates the transfer of melanosomes out of the melanocytes into adjacent keratinocytes (Chiaverini et al, 2008; Alves et al, 2017; Bahadoran et al, 2001; Fukuda et al, 2002; Nagashima et al, 2002; Kuroda and Fukuda, 2004; reviewed in Seabra and Coudrier, 2004; Hume and Seabra, 2011).
RAB27A and MYO5A are both direct targets of MITF-M as assessed by ChIP, EMSA and reporter gene assay (Chiaverini et al, 2008; Strub et al, 2011; Alves et al, 2017; reviewed in Cheli et al, 2010; Goding and Arnheiter, 2019).
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