Reactome | SDHA:SDHB binds to SDHC:SDHD

SDHA:SDHB binds to SDHC:SDHD

Stable Identifier

R-HSA-9855252

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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After translation in cytosol and translocation to the mitochondrial inner membrane SDH subunits C and D (SDHC, SDHD), together with the heme b cofactor, bind to the assembled cytosolic SDHA:SDHB construct to form the fully functional SDH complex. Although a full structure of the porcine complex exists (PDB 1ZOY) no details are known about the last steps of the assembly. However, successful assembly depends on the presence of both the SDHC heme b cofactor and the C-terminal tail of the SDHA subunit. (Lemarie & Grimm, 2009; Kim et al., 2012; reviewed in Van Vranken et al., 2014; Signes & Fernandez-Vizarra, 2018).

Literature References

PubMed ID	Title	Journal	Year
19332149	Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells Lemarié, A, Grimm, S	Mitochondrion	2009
23043141	Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit Kim, HJ, Na, U, Jeong, MY, Winge, DR	J Biol Chem	2012
25488574	Protein-mediated assembly of succinate dehydrogenase and its cofactors Rutter, J, Van Vranken, JG, Na, U, Winge, DR	Crit Rev Biochem Mol Biol	2015
30030361	Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes Signes, A, Fernandez-Vizarra, E	Essays Biochem	2018