SDHA binds to SDHB

Stable Identifier
R-HSA-9855212
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SDHA binds to SDHB
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The matured SDH subunits A and B (SDHA, SDHB) bind, releasing the chaperone SDHAF4 (Na et al., 2014; reviewed in Van Vranken et al., 2014).
Literature References
PubMed ID Title Journal Year
24954417 The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase

Yu, W, Thummel, CS, Rutter, J, Brockmann, K, Na, U, Winge, DR, Bricker, DK, Cox, J

Cell Metab 2014
25488574 Protein-mediated assembly of succinate dehydrogenase and its cofactors

Rutter, J, Van Vranken, JG, Na, U, Winge, DR

Crit Rev Biochem Mol Biol 2015
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein folding chaperone activity of SDHAF4 [mitochondrial matrix]

Physical Entity
SDHAF4 [mitochondrial matrix] (Homo sapiens)
Activity
protein folding chaperone (GO:0044183)
Orthologous Events
SDHA binds to SDHB (Bos taurus)
SDHA binds to SDHB (Mus musculus)
SDHA binds to SDHB (Sus scrofa)
SDHA binds to SDHB (Xenopus tropicalis)
Authored
Stephan, R  (2023-11-29)
Reviewed
Hill, DP  (2024-02-16)
Created
Stephan, R  (2023-11-29)
Cite Us!