Reactome | ACAT1 tetramer acetylates IDH2 dimer

ACAT1 tetramer acetylates IDH2 dimer

Stable Identifier

R-HSA-9854415

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

ReviewStatus

5/5

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All enzymes of the TCA cycle are highly acetylated at multiple lysine residues (reviewed in Zhao et al., 2010). The effects of this modification on enzyme activity are largely unknown. In the case of IDH2, however, acetylation by ACAT1 homotetramer at lysine 413 abolishes its activity (Chen et al., 2021), and thereby plays a major role in TCA cycle regulation.

Literature References

PubMed ID	Title	Journal	Year
20167786	Regulation of cellular metabolism by protein lysine acetylation An, W, Jiang, W, Hancock, SM, Zhou, L, Qin, L, Shi, J, Zeng, Y, Yao, J, Lin, Y, Zhao, S, Lei, Q, Xiong, Y, Chen, X, Guan, KL, Yu, W, Yang, P, Xu, W, He, F, Li, Y, Li, H, Zhang, T, Chin, J	Science	2010
34289383	Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells Lonial, S, Su, R, Zhang, R, Mao, H, Wu, R, Fan, H, Wang, M, He, C, Xia, S, Elf, SE, Famulare, CA, Gao, X, Chen, J, Stock, W, Chen, J, Le Beau, M, Odenike, O, Chen, D, Blum, WG, Arellano, M, Zhu, AC, Levine, RL, Boggon, TJ, Li, Y, Dong, L	Mol Cell	2021