Reactome | ACAT1 tetramer acetylates IDH2 dimer

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ACAT1 tetramer acetylates IDH2 dimer Show undefined attributes

catalystActivity	[CatalystActivity:11127500] acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
dbId	11127502
displayName	ACAT1 tetramer acetylates IDH2 dimer
eventOf	[Pathway:R-PFA-9854311] Maturation of TCA enzymes and regulation of TCA cycle - Plasmodium falciparum
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9854415] ACAT1 tetramer acetylates IDH2 dimer - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113559] Ac-CoA [mitochondrial matrix] [Complex:R-PFA-450982] IDH2 dimer [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	ACAT1 tetramer acetylates IDH2 dimer
output	[Complex:R-PFA-9854462] AcK-IDH2 dimer [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:170928] Plasmodium falciparum
stId	R-PFA-9854415
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-PFA-9854311] Maturation of TCA enzymes and regulation of TCA cycle
(inferredTo)	[Reaction:R-HSA-9854415] ACAT1 tetramer acetylates IDH2 dimer

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