Reactome | Transcriptional regulation of brown and beige adipocyte differentiation by EBF2

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Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Show undefined attributes

authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
created	[InstanceEdit:9844592] Orlic-Milacic, Marija, 2023-09-21
dbId	9844594
displayName	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
eventOf	[Pathway:R-HSA-9843743] Transcriptional regulation of brown and beige adipocyte differentiation - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9844360] EBF2 binds Blnc1 lncRNA - Homo sapiens [Reaction:R-HSA-9844366] EBF2 binds target gene loci - Homo sapiens [BlackBoxEvent:R-HSA-9844440] PPARG binds EBF2-bound gene loci - Homo sapiens [Reaction:R-HSA-9844375] ZNF423 binds EBF2 at EBF2-target gene loci - Homo sapiens [Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes - Homo sapiens [Reaction:R-HSA-9844425] SMAD1:SMAD4 trimer binds ZNF423 - Homo sapiens [BlackBoxEvent:R-HSA-9844415] PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 - Homo sapiens [BlackBoxEvent:R-HSA-9844536] PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD - Homo sapiens [BlackBoxEvent:R-HSA-9844549] UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD - Homo sapiens [BlackBoxEvent:R-HSA-9844600] CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD - Homo sapiens [BlackBoxEvent:R-HSA-9844598] DIO2 gene transcription is stimulated by EBF2 and repressed by ZNF423 - Homo sapiens [BlackBoxEvent:R-HSA-9844820] COX7A1 gene expression is stimulated by EBF2 - Homo sapiens [BlackBoxEvent:R-HSA-9844822] PPARGC1A gene expression is stimulated by EBF2 - Homo sapiens [BlackBoxEvent:R-HSA-9844818] ELOVL3 gene expression is stimulated by EBF2 and negatively regulated by ZNF423 - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9843754] Control of brown and beige fat development [LiteratureReference:9844613] Ebf2 is a selective marker of brown and beige adipogenic precursor cells [LiteratureReference:9844612] EBF2 determines and maintains brown adipocyte identity [LiteratureReference:9844362] A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation [LiteratureReference:9844565] Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators of Murine Brown Adipogenesis [LiteratureReference:9844614] EBF2 promotes the recruitment of beige adipocytes in white adipose tissue [LiteratureReference:9844390] Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program [LiteratureReference:9844400] Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation [LiteratureReference:9844609] EBF2 transcriptionally regulates brown adipogenesis via the histone reader DPF3 and the BAF chromatin remodeling complex [LiteratureReference:9844638] Id1 Promotes Obesity by Suppressing Brown Adipose Thermogenesis and White Adipose Browning [LiteratureReference:9828141] MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis [LiteratureReference:9845013] The tumor secretory factor ZAG promotes white adipose tissue browning and energy wasting [LiteratureReference:9844685] Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes [LiteratureReference:9844640] Loss of TLE3 promotes the mitochondrial program in beige adipocytes and improves glucose metabolism [LiteratureReference:9844687] BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning [LiteratureReference:9844394] ZFP423 controls EBF2 coactivator recruitment and PPAR? occupancy to determine the thermogenic plasticity of adipocytes [LiteratureReference:9844995] Factors affecting the induction of uncoupling protein 1 in C2C12 myogenic cells [LiteratureReference:9845012] Transcriptomic Analysis Reveals Fibroblast Growth Factor 11 (FGF11) Role in Brown Adipocytes in Thermogenic Regulation of Goats [LiteratureReference:9845005] Control of murine brown adipocyte development by GATA6 [LiteratureReference:9854521] A single-cell atlas of human and mouse white adipose tissue
maxDepth	2
modified	[InstanceEdit:9966045] Orlic-Milacic, Marija, 2025-09-09
name	Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
previousReviewStatus	[ReviewStatus:9821382] five stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9854531] Chun, Tae-Hwa, 2023-11-29
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9844594
summation	[Summation:9844998] EBF2 (Early B-cell factor 2) is a transcription factor that ...

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[Pathway:R-HSA-9843743] Transcriptional regulation of brown and beige adipocyte differentiation

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