Reactome | ZNF423 binds EBF2 at EBF2-target gene loci

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ZNF423 binds EBF2 at EBF2-target gene loci Show undefined attributes

authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9844374] Orlic-Milacic, Marija, 2023-09-16
dbId	9844375
displayName	ZNF423 binds EBF2 at EBF2-target gene loci
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
eventOf	[Pathway:R-HSA-9844594] Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 - Homo sapiens
followingEvent	[Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes - Homo sapiens [BlackBoxEvent:R-HSA-9844415] PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 - Homo sapiens
inferredFrom	[Reaction:R-MMU-9844373] Znf423 binds Ebf2 at Ebf2-target gene loci - Mus musculus
input	[CandidateSet:R-HSA-9844503] EBF2, EBF2:Blnc1 lncRNA:HNRNPU: PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, DIO2 gene, ELOVL3 gene) [nucleoplasm] 6 × [EntityWithAccessionedSequence:R-HSA-3222318] ZNF423 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9863215] Orlic-Milacic, Marija, 2024-02-27
name	ZNF423 binds EBF2 at EBF2-target gene loci
output	[CandidateSet:R-HSA-9844412] ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, PRDM16 gene, UCP1 gene, (CIDEA gene, DIO2 gene, ELOVL3 gene) [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9844366] EBF2 binds target gene loci - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
regulatedBy	[NegativeRegulation:9844429] Negative regulation by 'ZNF423:p-2S-SMAD1:p-2S-SMAD1:SMAD4 [nucleoplasm]'
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9854531] Chun, Tae-Hwa, 2023-11-29
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9844375
summation	[Summation:9844449] Based on studies in mice, the transcription factor ZNF423 (a...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9844415] PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 [Reaction:R-HSA-9844438] ZNF423 recruits NuRD to EBF2 target genes
(hasEvent)	[Pathway:R-HSA-9844594] Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
(inferredTo)	[Reaction:R-MMU-9844373] Znf423 binds Ebf2 at Ebf2-target gene loci

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