Reactome | PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423

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PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 Show undefined attributes

authored	[InstanceEdit:9844988] Orlic-Milacic, Marija, 2023-09-25
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9844414] Orlic-Milacic, Marija, 2023-09-16
dbId	9844415
displayName	PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423
edited	[InstanceEdit:9855181] Orlic-Milacic, Marija, 2023-11-29
eventOf	[Pathway:R-HSA-9844594] Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-MMU-9844775] Prdm16 gene expression is stimulated by Ebf2 and Pparg and inhibited by Znf423 - Mus musculus
input	[EntityWithAccessionedSequence:R-HSA-9844436] PRDM16 gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9863221] Orlic-Milacic, Marija, 2024-02-28
name	PRDM16 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423
output	[EntityWithAccessionedSequence:R-HSA-3222269] PRDM16 [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9844366] EBF2 binds target gene loci - Homo sapiens [Reaction:R-HSA-9844375] ZNF423 binds EBF2 at EBF2-target gene loci - Homo sapiens [BlackBoxEvent:R-HSA-9844440] PPARG binds EBF2-bound gene loci - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[NegativeGeneExpressionRegulation:9844540] Negative gene expression regulation by 'ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PRDM16 gene [nucleoplasm]' [PositiveGeneExpressionRegulation:9844789] Positive gene expression regulation by 'EBF2, EBF2:Blnc1 lncRNA:HNRNPU, Activated PPARG:RXRA:PRDM16 gene [nucleoplasm]'
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9854531] Chun, Tae-Hwa, 2023-11-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9844415
summation	[Summation:9844710] PRDM16 gene encodes histone-lysine N-methyltransferase PRDM1...

Referrals

(hasEvent)	[Pathway:R-HSA-9844594] Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
(inferredTo)	[BlackBoxEvent:R-MMU-9844775] Prdm16 gene expression is stimulated by Ebf2 and Pparg and inhibited by Znf423

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