Reactome | Signaling by LTK in cancer

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Signaling by LTK in cancer Show undefined attributes

authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
created	[InstanceEdit:9842653] Rothfels, Karen, 2023-08-27
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233
dbId	9842640
disease	[Disease:1500689] cancer [Disease:1247848] non-small cell lung carcinoma
displayName	Signaling by LTK in cancer
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-5663202] Diseases of signal transduction by growth factor receptors and second messengers - Homo sapiens
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-9842659] CLIP1(1-1083)-LTK(488-864) fusion dimerizes - Homo sapiens [Reaction:R-HSA-9842667] CLIP1-LTK fusion autophosphorylates - Homo sapiens [BlackBoxEvent:R-HSA-9845032] CLIP1-LTK fusion binds PI3K to activate AKT - Homo sapiens [Reaction:R-HSA-9845033] CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation - Homo sapiens
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9842429] ALK-activating homologous mutations in LTK induce cellular transformation [LiteratureReference:9842422] Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer [LiteratureReference:9842438] The CLIP1-LTK fusion is an oncogenic driver�in non-small-cell lung cancer
maxDepth	2
modified	[InstanceEdit:9863688] Rothfels, Karen, 2024-03-04
name	Signaling by LTK in cancer
normalPathway	[Pathway:R-HSA-9842663] Signaling by LTK
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9842640
summation	[Summation:9842650] LTK is a member of the anaplastic lymphoma kinase (ALK)/LTK ...

Referrals

(hasEvent)

[Pathway:R-HSA-5663202] Diseases of signal transduction by growth factor receptors and second messengers