Reactome | CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation

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CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation Show undefined attributes

authored	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9845036] Rothfels, Karen, 2023-09-26
crossReference	[DatabaseIdentifier:12020794] Mondo:0005233
dbId	9845033
disease	[Disease:1500689] cancer [Disease:1247848] non-small cell lung carcinoma
displayName	CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation
edited	[InstanceEdit:9851215] Rothfels, Karen, 2023-10-14
eventOf	[Pathway:R-HSA-9842640] Signaling by LTK in cancer - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-HSA-5675361] MAPK monomers and dimers [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:9842438] The CLIP1-LTK fusion is an oncogenic driver�in non-small-cell lung cancer
maxDepth	1
modified	[InstanceEdit:9863626] Rothfels, Karen, 2024-03-04
name	CLIP1-LTK promotes MAPK1 and MAPK3 phosphorylation
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-5674340] p-T,Y MAPK monomers and dimers [cytosol]
precedingEvent	[Reaction:R-HSA-9842667] CLIP1-LTK fusion autophosphorylates - Homo sapiens
regulatedBy	[PositiveRegulation:9845035] Positive regulation by 'CLIP1(1-1083)-p-6Y LTK(488-864) fusion dimer [plasma membrane]'
regulationReference	[RegulationReference:9845034] Positive regulation by 'CLIP1(1-1083)-p-6Y LTK(488-864) fusion dimer [plasma membrane]' The CLIP1-LTK fusion is an oncogenic driver�in non-small-cell lung cancer
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821383] three stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9845033
summation	[Summation:9845020] The CLIP1-LTK fusion promotes phosphorylation of MAPK1 and M...

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(hasEvent)

[Pathway:R-HSA-9842640] Signaling by LTK in cancer

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