Signaling by LTK in cancer

Stable Identifier
R-HSA-9842640
Type
Pathway
Species
Homo sapiens
ReviewStatus
3/5
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Signaling by LTK in cancer
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LTK is a member of the anaplastic lymphoma kinase (ALK)/LTK subfamily within the insulin receptor superfamily of RTKs. LTK encodes an 864-amino-acid protein consisting of extracellular, transmembrane, and tyrosine kinase domains and a short carboxy terminus. The LTK kinase domain shares 80% identity with ALK (Roll and Reuther, 2012). The biological role of LTK is not well defined under normal physiological conditions, and unlike ALK, a clear role for LTK in cancer is also not yet well established. LTK is overexpressed in leukemia, and high expression of LTK in early-stage non-small cell lung cancer (NSCLC) has been associated with greater risk of metastasis (Mueller-Tidow et al, 2005; Roll and Reuther, 2012). More recently, a novel CLIP1-LTK fusion protein has been identified in a small proportion of NSCLC cases (Izumi et al, 2021).
Literature References
PubMed ID Title Journal Year
22347506 ALK-activating homologous mutations in LTK induce cellular transformation

Reuther, GW, Roll, JD

PLoS One 2012
34819663 The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer

Ikeda, T, Nakachi, I, Watanabe, K, Kodani, M, Hayashi, K, Sakakibara-Konishi, J, Shibata, Y, Nishino, K, Izumi, H, Okamoto, I, Kirita, K, Goto, K, Nosaki, K, Yoh, K, Niho, S, Ishii, G, Matsumoto, S, Kuyama, S, Sakai, T, Liu, J, Furuya, N, Sugiyama, E, Nakai, T, Tanaka, K, Kumagai, S, Yamasaki, A, Daga, H, Zenke, Y, Taima, K, Ebi, N, Hayashida, T, Kato, T, Fukuhara, T, Mori, S, Kobayashi, SS, Udagawa, H, Ohtsu, A, Nakamura, A

Nature 2021
15753374 Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer

Berdel, WE, Serve, H, Thomas, M, Schneider, PM, Plewka, S, Schwäble, J, Müller-Tidow, C, Metzger, R, Brandts, CH, Steffen, B, Diederichs, S, Bulk, E, Pohle, T

Cancer Res 2005
Participants
Events
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as an event of
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Authored
Rothfels, K  (2023-10-14)
Created
Rothfels, K  (2023-08-27)
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