Signaling by LTK in cancer

Stable Identifier
R-HSA-9842640
Type
Pathway
Species
Homo sapiens
ReviewStatus
3/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Signaling by LTK in cancer
Click the image above or here to open this pathway in the Pathway Browser
LTK is a member of the anaplastic lymphoma kinase (ALK)/LTK subfamily within the insulin receptor superfamily of RTKs. LTK encodes an 864-amino-acid protein consisting of extracellular, transmembrane, and tyrosine kinase domains and a short carboxy terminus. The LTK kinase domain shares 80% identity with ALK (Roll and Reuther, 2012). The biological role of LTK is not well defined under normal physiological conditions, and unlike ALK, a clear role for LTK in cancer is also not yet well established. LTK is overexpressed in leukemia, and high expression of LTK in early-stage non-small cell lung cancer (NSCLC) has been associated with greater risk of metastasis (Mueller-Tidow et al, 2005; Roll and Reuther, 2012). More recently, a novel CLIP1-LTK fusion protein has been identified in a small proportion of NSCLC cases (Izumi et al, 2021).
Literature References
PubMed ID Title Journal Year
22347506 ALK-activating homologous mutations in LTK induce cellular transformation

Roll, JD, Reuther, GW

PLoS One 2012
34819663 The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer

Izumi, H, Matsumoto, S, Liu, J, Tanaka, K, Mori, S, Hayashi, K, Kumagai, S, Shibata, Y, Hayashida, T, Watanabe, K, Fukuhara, T, Ikeda, T, Yoh, K, Kato, T, Nishino, K, Nakamura, A, Nakachi, I, Kuyama, S, Furuya, N, Sakakibara-Konishi, J, Okamoto, I, Taima, K, Ebi, N, Daga, H, Yamasaki, A, Kodani, M, Udagawa, H, Kirita, K, Zenke, Y, Nosaki, K, Sugiyama, E, Sakai, T, Nakai, T, Ishii, G, Niho, S, Ohtsu, A, Kobayashi, SS, Goto, K

Nature 2021
15753374 Identification of metastasis-associated receptor tyrosine kinases in non-small cell lung cancer

Müller-Tidow, C, Diederichs, S, Bulk, E, Pohle, T, Steffen, B, Schwäble, J, Plewka, S, Thomas, M, Metzger, R, Schneider, PM, Brandts, CH, Berdel, WE, Serve, H

Cancer Res 2005
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
Mondo
Authored
Rothfels, K  (2023-10-14)
Created
Rothfels, K  (2023-08-27)
Cite Us!