Reactome | p-PKR dimer phosphorylates SPHK1

Schema > Reaction > Entries

p-PKR dimer phosphorylates SPHK1 Show undefined attributes

authored	[InstanceEdit:9836610] Stephan, Ralf, 2023-05-31
catalystActivity	[CatalystActivity:9836356] protein kinase activity of p-EIF2AK2 dimer [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9836614] Stephan, Ralf, 2023-05-31
dbId	9836617
displayName	p-PKR dimer phosphorylates SPHK1
edited	[InstanceEdit:9841954] Stephan, Ralf, 2023-08-16
eventOf	[Pathway:R-HSA-9833482] PKR-mediated signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9836621] p-S225-SPHK1 localizes to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9836616] SPHK1 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9836556] Cell fate determined by the activation balance between PKR and SPHK1
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	p-PKR dimer phosphorylates SPHK1
orthologousEvent	[Reaction:R-DDI-9836617] p-PKR dimer phosphorylates SPHK1 - Dictyostelium discoideum [Reaction:R-CEL-9836617] p-PKR dimer phosphorylates SPHK1 - Caenorhabditis elegans [Reaction:R-DME-9836617] p-PKR dimer phosphorylates SPHK1 - Drosophila melanogaster [Reaction:R-GGA-9836617] p-PKR dimer phosphorylates SPHK1 - Gallus gallus [Reaction:R-XTR-9836617] p-PKR dimer phosphorylates SPHK1 - Xenopus tropicalis [Reaction:R-SSC-9836617] p-PKR dimer phosphorylates SPHK1 - Sus scrofa [Reaction:R-BTA-9836617] p-PKR dimer phosphorylates SPHK1 - Bos taurus [Reaction:R-CFA-9836617] p-PKR dimer phosphorylates SPHK1 - Canis familiaris [Reaction:R-RNO-9836617] p-PKR dimer phosphorylates SPHK1 - Rattus norvegicus [Reaction:R-MMU-9836617] p-PKR dimer phosphorylates SPHK1 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9836613] p-S225-SPHK1 [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-9833635] p-PKR dimer localizes to the nucleus - Homo sapiens
releaseDate	2023-09-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9841953] Patel, Rekha C, 2023-08-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9836617
summation	[Summation:9836615] Activated PKR phosphorylates sphingosin kinase 1 (SPHK1) at ...

Referrals

(hasEvent)	[Pathway:R-HSA-9833482] PKR-mediated signaling
(precedingEvent)	[BlackBoxEvent:R-HSA-9836621] p-S225-SPHK1 localizes to cytosol