Reactome | Formation of peptide loading complex (PLC)

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Formation of peptide loading complex (PLC) Show undefined attributes

authored	[InstanceEdit:983164] Garapati, P V, 2010-10-29
category	binding
compartment	[Compartment:5263265] lumenal side of endoplasmic reticulum membrane [Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:983151] Garapati, P V, 2010-10-29
dbId	983142
displayName	Formation of peptide loading complex (PLC)
edited	[InstanceEdit:983164] Garapati, P V, 2010-10-29
eventOf	[Pathway:R-HSA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC - Homo sapiens
followingEvent	[Reaction:R-HSA-8951499] Loading of antigenic peptides on to class I MHC - Homo sapiens
input	[Polymer:R-HSA-983323] BAP31 oligomer [lumenal side of endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-985502] CALR [lumenal side of endoplasmic reticulum membrane] [Complex:R-HSA-983136] MHC HC:B2M:Erp57 [lumenal side of endoplasmic reticulum membrane] [Complex:R-HSA-983113] TAP [endoplasmic reticulum membrane] [EntityWithAccessionedSequence:R-HSA-983083] TAPBP [lumenal side of endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:982979] Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer [LiteratureReference:983316] The peptide-loading complex--antigen translocation and MHC class I loading [LiteratureReference:983315] The macromolecular peptide-loading complex in MHC class I-dependent antigen presentation [LiteratureReference:983433] Quality control of MHC class I maturation [LiteratureReference:1177545] A transmembrane tail: interaction of tapasin with TAP and the MHC class I molecule [LiteratureReference:1177546] Tapasin enhances MHC class I peptide presentation according to peptide half-life
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Formation of peptide loading complex (PLC)
orthologousEvent	[Reaction:R-SSC-983142] Formation of peptide loading complex (PLC) - Sus scrofa [Reaction:R-BTA-983142] Formation of peptide loading complex (PLC) - Bos taurus [Reaction:R-RNO-983142] Formation of peptide loading complex (PLC) - Rattus norvegicus [Reaction:R-MMU-983142] Formation of peptide loading complex (PLC) - Mus musculus
output	[Complex:R-HSA-983121] MHC:B2M peptide loading complex [endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-HSA-983146] Interaction of beta-2-microglobulin (B2M) chain with class I HC - Homo sapiens
releaseDate	2011-06-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1213482] Elliott, T, 2011-02-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-983142
summation	[Summation:982856] Upon interaction of Beta-2-microglobin (B2M) with MHC class ...
updateTrackers	[UpdateTracker:9782123] Update Tracker - [Reaction:983142] Formation of peptide loading complex (PLC) - v59:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9782123] Update Tracker - [Reaction:983142] Formation of peptide loading complex (PLC) - v59:[modifyText]
(hasEvent)	[Pathway:R-HSA-983170] Antigen Presentation: Folding, assembly and peptide loading of class I MHC
(precedingEvent)	[Reaction:R-HSA-8951499] Loading of antigenic peptides on to class I MHC

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