Reactome | Regulation of TBK1, IKK?-mediated activation of IRF3, IRF7 upon TLR3 ligation

Schema > Pathway > Entries

Regulation of TBK1, IKK?-mediated activation of IRF3, IRF7 upon TLR3 ligation Show undefined attributes

authored	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
created	[InstanceEdit:9828202] Shamovsky, Veronica, 2023-02-10
crossReference	[DatabaseIdentifier:12819455] BioModels Database:BIOMD0000000293 [DatabaseIdentifier:12819457] BioModels Database:BIOMD0000000220
dbId	9828211
displayName	Regulation of TBK1, IKK?-mediated activation of IRF3, IRF7 upon TLR3 ligation
edited	[InstanceEdit:9863258] Shamovsky, Veronica, 2024-02-28
eventOf	[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7 - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-9828200] TBK1 is ubiquitinated within TBK1:K63polyUb-TANK:K63polyUb-TRAF3:TRIF:activated TLR3 - Homo sapiens [BlackBoxEvent:R-HSA-9830710] IKK? (IKBKE) is ubiquitinated within the activated TLR3 complex - Homo sapiens [Reaction:R-HSA-9828209] OPTN binds TBK1 within the activated TLR3 complex - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9827943] The role of TBK1 in cancer pathogenesis and anticancer immunity [LiteratureReference:9827946] Negative regulation of TBK1-mediated antiviral immunity
maxDepth	2
modified	[InstanceEdit:12819426] Weiser, Joel, 2026-02-23
name	Regulation of TBK1, IKK?-mediated activation of IRF3, IRF7 upon TLR3 ligation Regulation of TBK1, IKBKE-mediated activation of IRF3, IRF7 upon TLR3 ligation
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863280] Muniti?, Ivana, Franjki?, Toni, 2024-02-28
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9828211
summation	[Summation:9828210] Production of type I IFN genes in response to Toll-like rece...

Referrals

(hasEvent)

[Pathway:R-HSA-9013973] TICAM1-dependent activation of IRF3/IRF7

Cite Us!