Reactome | Growth hormone receptor dimerizes

Growth hormone receptor dimerizes

Stable Identifier

R-HSA-982775

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

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The growth hormone receptor forms dimers (Cunningham et al. 1991) that subsequently signal via JAK2 (Argetsinger et al. 1993). Early studies suggested that dimerization occured following ligand binding, but it is now generally accepted that dimerization is independent of ligand binding and involves the transmembrane and juxtamembrane domains (van den Eijnden et al. 2006, Brown et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
1948064	Dimerization of the extracellular domain of the human growth hormone receptor by a single hormone molecule Cunningham, BC, Ultsch, M, de Vos, AM, Mulkerrin, MG, Clauser, KR, Wells, JA	Science	1991