Reactome | MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter

Schema > Reaction > Entries

MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter Show undefined attributes

authored	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9825866] Rothfels, Karen, 2023-01-27
dbId	9825848
displayName	MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter
edited	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
eventOf	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9824586] MITF-M-dependent DCT gene expression - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9824577] DCT gene [nucleoplasm] [Complex:R-HSA-9735197] LEF1:CTNNB1 [nucleoplasm] [Complex:R-HSA-9825710] MITF-M dimer [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-111910] p-S133-CREB1 [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-9613639] SOX10 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9855857] Positive and negative elements regulate a melanocyte-specific promoter [LiteratureReference:9855301] Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia [LiteratureReference:9824637] Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes [LiteratureReference:9855868] The Microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription [LiteratureReference:9855851] Pax3 functions at a nodal point in melanocyte stem cell differentiation [LiteratureReference:9854815] Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma [LiteratureReference:9855845] Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors [LiteratureReference:9824559] Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter
output	[Complex:R-HSA-9825863] MITF-M dimer:SOX10:p-S133 CREB1:LEF1:CTNNB1:DCT gene [nucleoplasm]
precedingEvent	[Reaction:R-HSA-9857375] MITF dimerizes - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9825848
summation	[Summation:9855878] Upregulation of DCT expression during melanogenesis depends ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9824586] MITF-M-dependent DCT gene expression
(hasEvent)	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation