MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter

Stable Identifier
R-HSA-9825848
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter
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Upregulation of DCT expression during melanogenesis depends on the binding of MITF-M to M- and E-box elements in its promoter, as assessed by reporter gene assay, electrophoretic mobility shift assay (EMSA) and chromatin immunoprecipitation (ChIP) (Lowings et al, 1992; Bertolotto et al, 1998a, b; Yavuzer et al, 1995; Lang et al, 2005; Strub et al, 2011). MITF-M appears to compete with PAX3 for binding at the DCT promoter, allowing a switch from the repressive PAX3:LEF1:TLE4 complex (Lang et al, 2005). Expression is additionally stimulated downstream of cAMP signaling by the binding of CREB1 to its cognate site (Bertolotto et al, 1998a), and through the concerted binding of SOX10, LEF1 and CTNNB1 (Ludwig et al, 2004, Yasumoto et al, 2002; Lang et al, 2005; reviewed in Cheli et al, 2010).
Literature References
PubMed ID Title Journal Year
15729346 Pax3 functions at a nodal point in melanocyte stem cell differentiation

Lang, D, Lu, MM, Huang, L, Engleka, KA, Zhang, M, Chu, EY, Lipner, S, Skoultchi, A, Millar, SE, Epstein, JA

Nature 2005
12032083 Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling

Yasumoto, K, Takeda, K, Saito, H, Watanabe, K, Takahashi, K, Shibahara, S

EMBO J 2002
7824265 The Microphthalmia gene product interacts with the retinoblastoma protein in vitro and is a target for deregulation of melanocyte-specific transcription

Yavuzer, U, Keenan, E, Lowings, P, Vachtenheim, J, Currie, G, Goding, CR

Oncogene 1995
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
9700169 Microphthalmia gene product as a signal transducer in cAMP-induced differentiation of melanocytes

Bertolotto, C, Abbe, P, Hemesath, TJ, Bille, K, Fisher, DE, Ortonne, JP, Ballotti, R

J Cell Biol 1998
1321344 Positive and negative elements regulate a melanocyte-specific promoter

Lowings, P, Yavuzer, U, Goding, CR

Mol Cell Biol 1992
14706856 Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors

Ludwig, A, Rehberg, S, Wegner, M

FEBS Lett 2004
9447965 Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) and of microphthalmia

Bertolotto, C, Buscà, R, Abbe, P, Bille, K, Aberdam, E, Ortonne, JP, Ballotti, R

Mol Cell Biol 1998
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Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-27)
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