Reactome | MITF-M-dependent DCT gene expression

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MITF-M-dependent DCT gene expression Show undefined attributes

authored	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:5668575] melanosome membrane
created	[InstanceEdit:9824591] Rothfels, Karen, 2023-01-20
dbId	9824586
displayName	MITF-M-dependent DCT gene expression
edited	[InstanceEdit:9825798] Rothfels, Karen, 2023-01-26
eventOf	[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9824577] DCT gene [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9855822] A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus [LiteratureReference:5662901] A second tyrosinase-related protein, TRP-2, is a melanogenic enzyme termed DOPAchrome tautomerase [LiteratureReference:9855839] Dopachrome tautomerase variants in patients with oculocutaneous albinism [LiteratureReference:5662718] Molecular characterization of a human tyrosinase-related-protein-2 cDNA. Patterns of expression in melanocytic cells [LiteratureReference:9731980] Fifteen-year quest for microphthalmia-associated transcription factor target genes [LiteratureReference:9824559] Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling [LiteratureReference:9855845] Melanocyte-specific expression of dopachrome tautomerase is dependent on synergistic gene activation by the Sox10 and Mitf transcription factors [LiteratureReference:9855851] Pax3 functions at a nodal point in melanocyte stem cell differentiation [LiteratureReference:9824555] Melanocyte-specific microphthalmia-associated transcription factor isoform activates its own gene promoter through physical interaction with lymphoid-enhancing factor 1 [LiteratureReference:9825375] Microphthalmia-associated transcription factor in the Wnt signaling pathway
maxDepth	1
modified	[InstanceEdit:9927681] Rothfels, Karen, 2024-11-08
name	MITF-M-dependent DCT gene expression
output	[EntityWithAccessionedSequence:R-HSA-5662685] DCT [melanosome membrane]
precedingEvent	[Reaction:R-HSA-9825848] MITF-M dimer, SOX10, pS133 CREB1 and CTNNB1:LEF1 bind the DCT promoter - Homo sapiens
previousReviewStatus	[ReviewStatus:9821383] three stars
regulatedBy	[PositiveGeneExpressionRegulation:9825891] Positive gene expression regulation by 'MITF-M dimer:SOX10:p-S133 CREB1:LEF1:CTNNB1:DCT gene [nucleoplasm]'
regulationReference	[RegulationReference:9825894] Positive gene expression regulation by 'MITF-M dimer:SOX10:p-S133 CREB1:LEF1:CTNNB1:DCT gene [nucleoplasm]' Pax3 functions at a nodal point in melanocyte stem cell differentiation
releaseDate	2024-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9863245] Arnheiter, Heinz, 2024-02-26 [InstanceEdit:9910860] de la Serna, Ivana L, 2024-05-21 [InstanceEdit:9927254] Vu, Hong Nhung, 2024-11-05 [InstanceEdit:9927252] Steingr�msson, Eir�kur, 2024-11-05
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9824586
summation	[Summation:9855879] DCT (also known as TYRP2) encodes L-dopachrome tautomerase, ...

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[Pathway:R-HSA-9824585] Regulation of MITF-M-dependent genes involved in pigmentation

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