Reactome | TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins

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TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10725144
displayName	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
eventOf	[Pathway:R-XTR-5205685] PINK1-PRKN Mediated Mitophagy - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9824897] p-S-TBK1 phosphorylates OPTN - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-XTR-9824896] TBK1:OPTN:K63-polyUb-mitochondrial proteins [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-XTR-9824891] p-S172-TBK1:OPTN:K63polyUb-mitochondrial proteins [mitochondrial outer membrane]
precedingEvent	[Reaction:R-XTR-9824888] OPTN, TBK1 bind ubiquitinated MOM proteins - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9824894
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5205685] PINK1-PRKN Mediated Mitophagy
(precedingEvent)	[Reaction:R-XTR-9824897] p-S-TBK1 phosphorylates OPTN
(inferredTo)	[Reaction:R-HSA-9824894] TBK1 is phosphorylated within TBK1:OPTN:Ub-mitochondrial proteins

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